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E2 displacement of CIP2A from TOPBP1 activates the DNA damage response during papillomavirus life cycles

2025-10-15

Abstract excerpt

The papillomavirus life cycle is intricately linked to epithelial differentiation, and the virus manipulates the differentiation process to facilitate viral production. One such manipulation is activation of the DNA damage response (DDR) which promotes viral replication via homologous recombination. This report demonstrates that the papillomavirus transcription/replication/segregation factor E2 activates the DNA d...

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Literature Corpus work
9c3c3f06-fdec-5395-bc8d-3d9b0a618e1e
DOI
10.1101/2025.10.15.682653
Open publication

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E2 displacement of CIP2A from TOPBP1 activates the DNA damage response during papillomavirus life cyclesDOI 10.1101/2025.10.15.682653
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