Genetic polymorphisms in the opioid receptor mu1 gene are associated with changes in libido and insomnia in methadone maintenance patients.

doi:10.1016/j.euroneuro.2012.02.002

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Article

Genetic polymorphisms in the opioid receptor mu1 gene are associated with changes in libido and insomnia in methadone maintenance patients.

European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology - 1 Oct 2012

Wang Sheng-Chang, Tsou Hsiao-Hui, Chen Chia-Hui, Chen Yu-Ting, Ho Ing-Kang, Hsiao Chin-Fu, Chou Sun-Yuan, Lin Yen-Feng, Fang Kai-Chi, Huang Chieh-Liang, Su Lien-Wen, Fang Yung-Chun, Liu Ming-Lun, Wu Hsiao-Yu, Lin Keh-Ming, Liu Shu Chih, Kuo Hsiang-Wei, Chiang I-Chen, Chen Andrew C H, Tian Jia-Ni, Liu Yu-Li

Abstract excerpt

Methadone, a synthetic racemic opioid that primarily works as a μ-opioid receptor (OPRM1) agonist, is commonly used for the treatment of heroin addiction. Genetic association studies have reported that the OPRM1 gene is involved in the physiology of heroin and alcohol addiction. Our current study is designed to test the hypothesis that genetic polymorphisms in the OPRM1 gene region are associated with methadone...

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Identifiers

PMID: 22406240
DOI: 10.1016/j.euroneuro.2012.02.002

Genes

OPRM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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