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Article

Characterization of the thyroxine-binding site of thyroxine-binding globulin by site-directed mutagenesis.

Molecular endocrinology (Baltimore, Md.) - 1 Nov 1999

Buettner C, Grasberger H, Hermansdorfer K, Chen B, Treske B, Janssen O E

Abstract excerpt

The principal transport protein for T4 in human blood, thyroxine-binding globulin (TBG), binds T4 with an exceptionally high affinity (Ka = 10(10) M(-1)). Its homology to the superfamily of the serpins has recently been used in the design of chimeric proteins, providing experimental evidence that an eight-stranded beta-barrel domain encompasses the ligand-binding site. We have now characterized the T4 binding...

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Identifiers

PMID: 10551780
DOI: 10.1210/mend.13.11.0367

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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