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Article

Selection of zidovudine resistance mutations and escape of human immunodeficiency virus type 1 from antiretroviral pressure in stavudine-treated pediatric patients.

The Journal of infectious diseases - 15 Apr 2002

Maxeiner Horst-Guenter, Keulen Wilco, Schuurman Rob, Bijen Marc, de Graaf Loek, van Wijk Albert, Back Nicole, Kline Mark W, Boucher Charles A B, Nijhuis Monique

Abstract excerpt

The relationship between clinical changes in stavudine activity and stavudine resistance was investigated in 16 human immunodeficiency virus (HIV)-infected children who received stavudine monotherapy for 18 months. Seven patients responded well to stavudine therapy, 3 experienced transient reductions in virus load, and all others had no detectable virologic response. In both the responders and nonresponders, no...

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Share to Acquired Immunodeficiency Syndrome
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Drug Resistance, Viral

Share to HIV Reverse Transcriptase

Share to Mutagenesis, Site-Directed

Share to Stavudine

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Source

Identifiers

PMID: 11930317
DOI: 10.1086/339817

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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