Article
Diminished selection for thymidine-analog mutations associated with the presence of M184V in Ethiopian children infected with HIV subtype C receiving lamivudine-containing therapy.
The Pediatric infectious disease journal - 1 Nov 2006
Averbuch Diana, Schapiro Jonathan M, Lanier E Randall, Gradstein Serge, Gottesman Giora, Kedem Eynat, Einhorn Menachem, Grisaru-Soen Galia, Ofir Michal, Engelhard Dan, Grossman Zehava
Abstract excerpt
BACKGROUND: We retrospectively studied the effect of the lamivudine-induced reverse transcription mutation M184V on selection of thymidine analog mutations (TAMs) in HIV subtype C-infected children and on clinical outcome. METHODS: We genotyped 135 blood samples from 55 children. TAMs accumulatio...
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