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Article

Imputing causality and clonal dynamics from single-cell transcriptomics in paroxysmal nocturnal hemoglobinuria.

Leukemia - 1 Jul 2026

Mizumaki Hiroki, Gao Shouguo, Wu Zhijie, Gutierrez-Rodrigues Fernanda, Alemu Lemlem, Quinones Raffo Diego, Darden Ivana, Rios Olga, Lotter Jennifer, Kajigaya Sachiko, Durrani Jibran, Groarke Emma M, Patel Bhavisha A, Young Neal S

Abstract excerpt

Paroxysmal nocturnal hemoglobinuria (PNH) originates from hematopoietic stem cells (HSCs) harboring somatic mutations in the phosphatidylinositol glycan class A (PIGA) gene. Clonal expansion of PIGA-mutated cells occurs uniquely in the setting of bone marrow (BM) failure, but specific pathophysiologic mechanisms remain unclear. We performed single-cell RNA sequencing (scRNA-seq) of BM cells from patients with...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42020783
DOI: 10.1038/s41375-026-02914-5
PMCID: PMC13323074

Genes

PIGA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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