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Article

Influence of polymorphic metabolic enzymes on biotransformation and effects of diphenylmethane diisocyanate.

International archives of occupational and environmental health - 1 Feb 2008

Littorin Margareta, Hou Saimei, Broberg Karin, Björk Jonas, Fält Susanne, Abdoulaye Galbani, Kalemba Malgorzata, Ryk Charlotta, Skerfving Staffan

Abstract excerpt

OBJECTIVES: To identify effect modification produced by genetic traits found in metabolic enzymes, to investigate how these affect the levels of different biomarkers of sprayed and thermo-degraded polyurethane (PUR) based on 4,4'-diphenylmethane diisocyanate (MDI) and to determine how associated respiratory disorders are affected. METHODS: Two partly overlapping groups of 141 and 158 factory employees exposed to...

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Source

Identifiers

PMID: 17676332
DOI: 10.1007/s00420-007-0232-x

Genes

GSTP1
NAT2
GSTT1
GSTM1
GSTM3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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