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Identification of a binding pocket of letermovir in the terminase subunit pUL56 of human cytomegalovirus

25 Mar 2025

Abstract excerpt

A key step in replication of human cytomegalovirus (HCMV) is the generation and packaging of unit-length genomes into preformed capsids. The enzymes involved in this process are viral terminases. The HCMV terminase consists of two subunits, the ATPase pUL56 and the nuclease pUL89. A potential third component, pUL51, has been proposed. Letermovir is the first terminase inhibitor available for HCMV prophylaxis to...

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PMID: 40133489
DOI: 10.1038/s41598-025-94809-1

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