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The Human Cytomegalovirus UL51 Protein Is Essential for Viral Genome Cleavage-Packaging and Interacts with the Terminase Subunits pUL56 and pUL89

23 Nov 2012

Abstract excerpt

Cleavage of human cytomegalovirus (HCMV) genomes as well as their packaging into capsids is an enzymatic process mediated by viral proteins and therefore a promising target for antiviral therapy. The HCMV proteins pUL56 and pUL89 form the terminase and play a central role in cleavage-packaging, but several additional viral proteins, including pUL51, had been suggested to contribute to this process, although they...

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PMID: 23175377
DOI: 10.1128/jvi.01955-12

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The Human Cytomegalovirus UL51 Protein Is Essential for Viral Genome Cleavage-Packaging and Interacts with the Terminase Subunits pUL56 and pUL89PMID 23175377Read ↗

The C-terminal part of the human cytomegalovirus terminase subunit pUL51 is central for terminase complex assembly.Semantic proximity Read ↗

Interaction of human cytomegalovirus pUL52 with major components of the viral DNA encapsidation network underlines its essential role in genome cleavage-packagingSemantic proximity Read ↗

The Essential Human Cytomegalovirus Gene UL52 Is Required for Cleavage-Packaging of the Viral GenomeSemantic proximity Read ↗

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Mutual Interplay between the Human Cytomegalovirus Terminase Subunits pUL51, pUL56, and pUL89 Promotes Terminase Complex FormationSemantic proximity Read ↗

The Essential Human Cytomegalovirus Proteins pUL77 and pUL93 Are Structural Components Necessary for Viral Genome EncapsidationSemantic proximity Read ↗

Identification of the Interaction Domain of the Small Terminase Subunit pUL89 with the Large Subunit pUL56 of Human CytomegalovirusSemantic proximity Read ↗

Human cytomegalovirus terminase as a target for antiviral chemotherapySemantic proximity Read ↗

Identification of a short sequence in the HCMV terminase pUL56 essential for interaction with pUL89 subunitSemantic proximity Read ↗

The human cytomegalovirus terminase complex as an antiviral target: a close-up viewSemantic proximity Read ↗

Key domains involved in the interaction and assembly of the HCMV terminase complex.Semantic proximity Read ↗

Identification of Human Cytomegalovirus Genes Important for Biogenesis of the Cytoplasmic Virion Assembly ComplexSemantic proximity Read ↗

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