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Article

Broad nucleoside-analogue resistance implications for human immunodeficiency virus type 1 reverse-transcriptase mutations at codons 44 and 118.

The Journal of infectious diseases - 1 Apr 2002

Romano Laura, Venturi Giulietta, Bloor Stuart, Harrigan Richard, Larder Brendan A, Major Jennifer C, Zazzi Maurizio

Abstract excerpt

Two large, independent human immunodeficiency virus type 1 resistance databases containing >7700 reverse-transcriptase (RT) sequences were used to analyze the epidemiology of amino acid substitutions at codons 44 and 118, which confer moderate lamivudine resistance in the presence of zidovudine resistance. As expected, E44A/D and V118I mutations were strongly associated with M41L, D67N, L210W, and T215Y but also...

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Source

Identifiers

PMID: 11920313
DOI: 10.1086/339706

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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