Article
Prevalence and conditions of selection of E44D/A and V118I human immunodeficiency virus type 1 reverse transcriptase mutations in clinical practice.
Antimicrobial agents and chemotherapy - 1 Mar 2001
Delaugerre C, Mouroux M, Yvon-Groussin A, Simon A, Angleraud F, Huraux J M, Agut H, Katlama C, Calvez V
Abstract excerpt
Recently, it has been shown that a new mutational pattern (the E44D/A and/or V118I mutation) confers moderate phenotypic lamivudine resistance in the absence of the M184V mutation. The E44D/A and/or the V118I mutation does not exist in drug-naive patients, and the prevalence increases with the number of treatment regimens and lamivudine experience. The mutations can preexist in nucleoside-experienced but...
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