Article
The V118I mutation as a marker of advanced HIV infection and disease progression.
Antiviral therapy - 1 Jan 2007
Zaccarelli Mauro, Tozzi Valerio, Lorenzini Patrizia, Forbici Federica, Narciso Pasquale, Ceccherini-Silberstein Francesca, Trotta Maria Paola, Bertoli Ada, Liuzzi Giuseppina, Marconi Patrizia, Mosti Silvia, Perno Carlo Federico, Antinori Andrea
Abstract excerpt
BACKGROUND: The V118I mutation is included in the nucleoside analogue mutations (NAMs) set. It contributes to thymidine-analogue resistance and, consequently, to resistance to the whole nucleoside reverse transcriptase inhibitor (NRTI) class. We focused on the V1181 mutation in order to evaluate factors associated with its detection and its relationship with HIV progression. METHODS: Clinical and laboratory data...
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