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Article

Raf-1 activation disrupts its binding to keratins during cell stress.

The Journal of cell biology - 16 Aug 2004

Ku Nam-On, Fu Haian, Omary M Bishr

Abstract excerpt

Keratins 8 and 18 (K8/18) heteropolymers may regulate cell signaling via the known K18 association with 14-3-3 proteins and 14-3-3 association with Raf-1 kinase. We characterized Raf-keratin-14-3-3 associations and show that Raf associates directly with K8, independent of Raf kinase activity or R...

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Share to 14-3-3 Proteins
Share to Keratins
Share to Mitogen-Activated Protein Kinase 1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 15314064
DOI: 10.1083/jcb.200402051
PMCID: PMC2172217

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-15314064-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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