Phosphorylation of human keratin 18 serine 33 regulates binding to 14-3-3 proteins.

doi:10.1093/emboj/17.7.1892

Back to search

Article

Phosphorylation of human keratin 18 serine 33 regulates binding to 14-3-3 proteins.

The EMBO journal - 1 Apr 1998

Ku N O, Liao J, Omary M B

Abstract excerpt

Members of the 14-3-3 protein family bind the human intermediate filament protein keratin 18 (K18) in vivo, in a cell-cycle- and phosphorylation-dependent manner. We identified K18 Ser33 as an interphase phosphorylation site, which increases its phosphorylation during mitosis in cultured cells an...

Topics

14-3-3 Proteins
3T3 Cells
Animals
Antibody Specificity
Cell Line
Cricetinae
HT29 Cells
Humans
Intermediate Filaments
Keratins
Liver
Liver Regeneration
Mice
Mitosis
Mutation
Peptide Mapping
Phosphorylation
Protein Binding

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.