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Article

Rational design of coagulation factor VIIa variants with substantially increased intrinsic activity.

Proceedings of the National Academy of Sciences of the United States of America - 20 Nov 2001

Persson E, Kjalke M, Olsen O H

Abstract excerpt

A trace amount of coagulation factor VII (FVII) circulates in the blood in the activated form, FVIIa (EC 3.4.21.21), formed by internal proteolysis. To avoid disseminated thrombus formation, FVIIa remains in a conformation with zymogen-like properties. Association with tissue factor (TF), locally...

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Identifiers

PMID: 11698657
DOI: 10.1073/pnas.241339498
PMCID: PMC61084

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-11698657-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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