Article
Rational design of coagulation factor VIIa variants with substantially increased intrinsic activity.
Proceedings of the National Academy of Sciences of the United States of America - 20 Nov 2001
Persson E, Kjalke M, Olsen O H
Abstract excerpt
A trace amount of coagulation factor VII (FVII) circulates in the blood in the activated form, FVIIa (EC 3.4.21.21), formed by internal proteolysis. To avoid disseminated thrombus formation, FVIIa remains in a conformation with zymogen-like properties. Association with tissue factor (TF), locally exposed upon vascular injury, is necessary to render FVIIa biologically active and initiate blood clotting. We have...
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