Activity, folding, misfolding, and aggregation in vitro of the naturally occurring human tissue factor mutant R200W.

Abstract excerpt

Tissue factor (TF), a small transmembrane receptor, binds factor VIIa (FVIIa), and the formed complex initiates blood coagulation by proteolytic activation of substrate factors IX and X. A naturally occurring mutation in the human TF gene was recently reported, where a single-base substitution results in an R200W mutation in the TF extracellular domain [Zawadzki, C., Preudhomme, C., Gaveriaux, V., Amouyel, P.,...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Amyloid
• Share to Benzothiazoles