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Article

Mitochondrial uncoupling protein-2 mediates steatotic liver injury following ischemia/reperfusion.

The Journal of biological chemistry - 28 Mar 2008

Evans Zachary P, Ellett Justin D, Schmidt Michael G, Schnellmann Rick G, Chavin Kenneth D

Abstract excerpt

Steatotic livers are not used for transplantation because they have a reduced tolerance for ischemic events with reduced ATP levels and greater levels of cellular necrosis, which ultimately result in total organ failure. Mitochondrial uncoupling protein-2 (UCP2) is highly expressed in steatotic livers and may be responsible for liver sensitivity to ischemia through mitochondrial and ATP regulation. To test this...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 18086675
DOI: 10.1074/jbc.M706784200
PMCID: PMC2417178

Genes

UCP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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