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Enhanced skin carcinogenesis in cyclin D1-conditional transgenic mice: cyclin D1 alters keratinocyte response to calcium-induced terminal differentiation.

Cancer research - 15 Mar 2002

Yamamoto Hanako, Ochiya Takahiro, Takeshita Fumitaka, Toriyama-Baba Hiroyasu, Hirai Kotaro, Sasaki Hideo, Sasaki Hiroki, Sakamoto Hiromi, Yoshida Teruhiko, Saito Izumu, Terada Masaaki

Abstract excerpt

Cyclin D1 is a critical gene involved in the regulation of progression through the G(1) phase of the cell cycle, thereby contributing to cell proliferation. Gene amplification and abnormal expression of Cyclin D1 have been described in several human cancers. To understand their biological significance in skin carcinogenesis, we established Cyclin D1-conditional transgenic mice with C57BL/6J background, in which...

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PMID: 11912134

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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