Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

TGFBI deficiency predisposes mice to spontaneous tumor development.

Cancer research - 1 Jan 2009

Zhang Ye, Wen Gengyun, Shao Genze, Wang Cuidong, Lin Chyuansheng, Fang Hongbo, Balajee Adayabalam S, Bhagat Govind, Hei Tom K, Zhao Yongliang

Abstract excerpt

Loss of TGFBI, a secreted protein induced by transforming growth factor-beta, has been implicated in cell proliferation, tumor progression, and angiogenesis by in vitro studies. However, in vivo antitumor functions of TGFBI as well as the underlying molecular mechanism are not well understood. To these aims, we have generated a mouse model with disruption of TGFBI genomic locus. Mice lacking TGFBI show a retarded...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cyclin D1
Share to 9,10-Dimethyl-1,2-benzanthracene

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cyclic AMP Response Element-Binding Protein

Share to G1 Phase

Share to Genes, Tumor Suppressor

Share to Neoplasms, Experimental

Share to S Phase

Share to Transforming Growth Factor beta1

Source

Open in PubMed Open full text

Identifiers

PMID: 19117985
DOI: 10.1158/0008-5472.CAN-08-1648
PMCID: PMC2664305

Genes

TGFBI

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

TGFBI deficiency predisposes mice to spontaneous tumor development.PMID 19117985Read ↗

The role of TGFBI in mesothelioma and breast cancer: association with tumor suppressionSemantic proximity Read ↗

The role of TGFBI (βig-H3) in gastrointestinal tract tumorigenesisSemantic proximity Read ↗

A functional connection between pRB and transforming growth factor beta in growth inhibition and mammary gland development.Semantic proximity Read ↗

TGFBR1*6A enhances breast cancer development through downregulation of p27Semantic proximity Read ↗

TGFBI expression is associated with a better response to chemotherapy in NSCLCSemantic proximity Read ↗

Epigenetic Alteration of the Cancer-Related Gene TGFBI in B Cells Infected with Epstein–Barr Virus and Exposed to Aflatoxin B1: Potential Role in Burkitt Lymphoma DevelopmentSemantic proximity Read ↗

Mouse models of transforming growth factor β impact in breast development and cancerSemantic proximity Read ↗

Transforming growth factor-β-induced protein (TGFBI) suppresses mesothelioma progression through the Akt/mTOR pathway.Semantic proximity Read ↗

Loss of the Birt–Hogg–Dubé tumor suppressor results in apoptotic resistance due to aberrant TGFβ-mediated transcriptionSemantic proximity Read ↗

Enhanced Expression of TGFBI Promotes the Proliferation and Migration of Glioma CellsSemantic proximity Read ↗

Oncogenic Signaling Pathways Activated in DMBA-Induced Mouse Mammary TumorsSemantic proximity Read ↗

A transcriptionally active pRb–E2F1–P/CAF signaling pathway is central to TGFβ-mediated apoptosisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.