Repression of the alpha-fetoprotein gene promoter by progesterone and chimeric receptors in the presence of hormones and antihormones.

doi:10.1128/mcb.10.9.5002-5006.1990

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Article

Repression of the alpha-fetoprotein gene promoter by progesterone and chimeric receptors in the presence of hormones and antihormones.

Molecular and cellular biology - 1 Sept 1990

Turcotte B, Meyer M E, Bocquel M T, Bélanger L, Chambon P

Abstract excerpt

Using transient transfection assays, we showed that repression of the alpha-fetoprotein promoter by intact and deletion mutants of the progesterone receptor and by chimeric progesterone/glucocorticoid-estrogen receptors in the presence of their cognate hormones was closely correlated with their ability to bind to a progesterone/glucocorticoid-responsive element. This negative regulation was also observed in the...

Topics

Animals
Base Sequence
Cell Line
Chickens
Chimera
Chromosome Deletion
Genes
Humans
Mifepristone
Molecular Sequence Data
Mutation
Oligonucleotide Probes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Progesterone

Promegestone

Promoter Regions, Genetic

Receptors, Progesterone

Restriction Mapping

Tamoxifen

Source

Open in PubMed Open full text

Identifiers

PMID: 1697036
DOI: 10.1128/mcb.10.9.5002-5006.1990
PMCID: PMC361135

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1697036-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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