Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A genomic screen in yeast reveals novel aspects of nonstop mRNA metabolism.

Genetics - 1 Oct 2007

Wilson Marenda A, Meaux Stacie, van Hoof Ambro

Abstract excerpt

Nonstop mRNA decay, a specific mRNA surveillance pathway, rapidly degrades transcripts that lack in-frame stop codons. The cytoplasmic exosome, a complex of 3'-5' exoribonucleases involved in RNA degradation and processing events, degrades nonstop transcripts. To further understand how nonstop mRNAs are recognized and degraded, we performed a genomewide screen for nonessential genes that are required for nonstop...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adaptor Proteins, Signal Transducing
Share to Codon, Terminator
Share to Exoribonucleases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genome, Fungal

Share to Inositol Phosphates

Share to Proteasome Endopeptidase Complex

Share to RNA Stability

Share to Saccharomyces cerevisiae Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 17660569
DOI: 10.1534/genetics.107.073205
PMCID: PMC2034642

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A genomic screen in yeast reveals novel aspects of nonstop mRNA metabolism.PMID 17660569Read ↗

Exosome-mediated recognition and degradation of mRNAs lacking a termination codon.Semantic proximity Read ↗

Quality control of eukaryotic mRNA: safeguarding cells from abnormal mRNA function.Semantic proximity Read ↗

mRNA quality control: an ancient machinery recognizes and degrades mRNAs with nonsense codons.Semantic proximity Read ↗

Characterization of cis-acting sequences and decay intermediates involved in nonsense-mediated mRNA turnover.Semantic proximity Read ↗

Nonsense-mediated mRNA decay modulates clinical outcome of genetic disease.Semantic proximity Read ↗

Making sense of nonsense in yeast.Semantic proximity Read ↗

A Haploid Genetic Screening Method for Proteins Influencing Mammalian Nonsense-Mediated mRNA Decay ActivitySemantic proximity Read ↗

Nonsense-mediated mRNA decayin health and diseaseSemantic proximity Read ↗

A novel nonstop mutation in TYMP does not induce nonstop mRNA decay in a MNGIE patient with severe neuropathy.Semantic proximity Read ↗

The 3' to 5' degradation of yeast mRNAs is a general mechanism for mRNA turnover that requires the SKI2 DEVH box protein and 3' to 5' exonucleases of the exosome complex.Semantic proximity Read ↗

Rapid deadenylation triggered by a nonsense codon precedes decay of the RNA body in a mammalian cytoplasmic nonsense-mediated decay pathway.Semantic proximity Read ↗

Copper tolerance of Saccharomyces cerevisiae nonsense-mediated mRNA decay mutants.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.