Article

A single BRCA2 BRC repeat supports viability while multiple repeats ensure resilience under stress

2026-01-08

Abstract excerpt

BRC repeats are integral to BRCA2 function and mediate RAD51 loading during homologous recombination (HR). Their number varies across species, but mammals, including mice and humans, harbor eight repeats. Prior studies have suggested functional redundancy among these repeats, but the biological significance of maintaining multiple repeats remains unresolved. Here, we demonstrate that the presence of a single BRC r...

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Literature Corpus work: b8e3c793-6d3b-58b7-ae08-ec43ddd5adc8
DOI: 10.64898/2026.01.07.698272

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