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Article

Janus kinase 3: the controller and the controlled.

Acta biochimica et biophysica Sinica - 1 Mar 2012

Wu Wei, Sun Xiao-Hong

Abstract excerpt

Janus kinase (JAK)-signal transducer and activators of transcription (STAT) signaling pathways play crucial roles in lymphopoiesis. In particular, JAK3 has unique functions in the lymphoid system such that JAK3 ablation results in phenotypes resembling severe combined immunodeficiency syndrome. This review focuses on the biochemistry, immunological functions, and clinical significance of JAK3. Compared with other...

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Source

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Identifiers

PMID: 22130498
DOI: 10.1093/abbs/gmr105
PMCID: PMC3284110

Genes

JAK3
JAK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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