Article
Anxiety and increased 5-HT1A receptor response in NCAM null mutant mice.
Journal of neurobiology - 5 Sept 1999
Stork O, Welzl H, Wotjak C T, Hoyer D, Delling M, Cremer H, Schachner M
Abstract excerpt
Mice deficient in the neural cell adhesion molecule (NCAM) show behavioral abnormalities as adults, including altered exploratory behavior, deficits in spatial learning, and increased intermale aggression. Here, we report increased anxiety-like behavior of homozygous (NCAM-/-) and heterozygous (NCAM/-) mutant mice in a light/dark avoidance test, independent of genetic background and gender. Anxiety-like behavior...
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