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Article

Wild-type intracellular bacteria deliver DNA into mammalian cells

1 Mar 2002

Abstract excerpt

Gene transfer in vitro from intracellular bacteria to mammalian phagocytic and non-phagocytic cells and in vivo in mice has been reported. The bacteria used as DNA delivery vectors were engineered to lyze upon entry in the cell due to impaired cell wall synthesis for Shigella flexneri and invasive Escherichia coli, or production of a phage lysin for Listeria mono- cytogenes. In vivo gene transfer was obtained...

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Identifiers

PMID: 11906454
DOI: 10.1046/j.1462-5822.2002.00184.x

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