Article
Presentation of Listeria monocytogenes antigens by major histocompatibility complex class I molecules to CD8 cytotoxic T lymphocytes independent of listeriolysin secretion and virulence.
European journal of immunology - 1 Jul 1994
Szalay G, Hess J, Kaufmann S H
Abstract excerpt
Virulence and intracellular persistence of Listeria monocytogenes markedly depend on secretion of listeriolysin (Hly), which promotes invasion of the pathogen from the endosome into the cytosol. Recent studies have provided compelling evidence that Hly also facilitates recognition of listerial antigens, in association with major histocompatibility complex (MHC) class I molecules, by CD8 T lymphocytes. Data...
Topics
- Animals
- Antigen Presentation
- Antigens, Bacterial
- Bacterial Toxins
- Base Sequence
- CD8 Antigens
- Cells, Cultured
- Female
- Heat-Shock Proteins
- Hemolysin Proteins
- Histocompatibility Antigens Class I
