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Article

Use of Native Lactococci as Vehicles for Delivery of DNA into Mammalian Epithelial Cells

1 Nov 2006

Abstract excerpt

The use of the food-grade bacterium Lactococcus lactis as a DNA delivery vehicle at the mucosal level is an attractive DNA vaccination strategy. Previous experiments showed that recombinant L. lactis expressing the Listeria monocytogenes inlA gene can deliver a functional gene into mammalian cells. Here, we explored the potential use of noninvasive L. lactis strains as a DNA delivery vehicle. We constructed two...

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PMID: 16963550
DOI: 10.1128/aem.01325-06

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