Article
Dominant-negative HMGA1 blocks mu enhancer activation through a novel mechanism.
Biochemical and biophysical research communications - 29 Mar 2002
Andreucci Amy, Reeves Raymond, McCarthy Kevin M, Nikolajczyk Barbara S
Abstract excerpt
The immunoglobulin mu intronic enhancer is a potent B cell-specific transcriptional activator. The enhancer is activated by the appropriate combination of transcription factors, amongst which are ets and bHLH proteins. HMGA1 (formerly HMG-I(Y)) is a demonstrated co-activator of the mu enhancer. HMGA1 functions through direct interaction with PU.1, one of the ets proteins critical for enhancer activation. New data...
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