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Article

ICOS gene polymorphisms are associated with sporadic breast cancer: a case-control study.

BMC cancer - 15 Sept 2011

Xu Fengyan, Li Dalin, Zhang Qiujin, Fu Zhenkun, Zhang Jie, Yuan Weiguang, Chen Shuang, Pang Da, Li Dianjun

Abstract excerpt

BACKGROUND: Inducible costimulator (ICOS), a costimulatory molecular of the CD28 family, provides positive signal to enhance T cell proliferation. Its abnormal expression can disturb the immune response and entail an increased risk of cancer. To investigate whether single nucleotide polymorphisms (SNPs) in the ICOS gene are associated with sporadic breast cancer susceptibility and progression in Chinese women, a...

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Source

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Identifiers

PMID: 21917182
DOI: 10.1186/1471-2407-11-392
PMCID: PMC3185281

Genes

ICOS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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