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Article

APC, signal transduction and genetic instability in colorectal cancer.

Nature reviews. Cancer - 1 Oct 2001

Fodde R, Smits R, Clevers H

Abstract excerpt

Colorectal cancer arises through a gradual series of histological changes, each of which is accompanied by a specific genetic alteration. In general, an intestinal cell needs to comply with two essential requirements to develop into a cancer: it must acquire selective advantage to allow for the initial clonal expansion, and genetic instability to allow for multiple hits in other genes that are responsible for...

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Identifiers

PMID: 11900252
DOI: 10.1038/35094067

Genes

APC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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