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Article

Local DNA topology and gene expression: the case of the leu-500 promoter.

Molecular microbiology - 1 Apr 1991

Lilley D M, Higgins C F

Abstract excerpt

Many promoters are sensitive to DNA supercoiling, and it is becoming apparent that this may play an important role in gene regulation. The twin supercoiled-domain hypothesis (Liu and Wang, 1987) proposes that transcription can lead to local variation in supercoiling. The mutant leu-500 promoter has presented a long-standing problem to the understanding of the control of promoter function by DNA supercoiling. This...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 1857204
DOI: 10.1111/j.1365-2958.1991.tb00749.x

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Source receipt: pubmed, retrieved 7 Sept 2026.

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