Article
Local DNA topology and gene expression: the case of the leu-500 promoter.
Molecular microbiology - 1 Apr 1991
Lilley D M, Higgins C F
Abstract excerpt
Many promoters are sensitive to DNA supercoiling, and it is becoming apparent that this may play an important role in gene regulation. The twin supercoiled-domain hypothesis (Liu and Wang, 1987) proposes that transcription can lead to local variation in supercoiling. The mutant leu-500 promoter has presented a long-standing problem to the understanding of the control of promoter function by DNA supercoiling. This...
Topics
- DNA, Bacterial
- DNA, Superhelical
- Gene Expression Regulation, Bacterial
- Models, Genetic
- Mutation
- Nucleic Acid Conformation
- Promoter Regions, Genetic
- Salmonella typhimurium
- Transcription, Genetic