Article
Fiber knob modifications overcome low, heterogeneous expression of the coxsackievirus-adenovirus receptor that limits adenovirus gene transfer and oncolysis for human rhabdomyosarcoma cells.
Cancer research - 1 Apr 2001
Cripe T P, Dunphy E J, Holub A D, Saini A, Vasi N H, Mahller Y Y, Collins M H, Snyder J D, Krasnykh V, Curiel D T, Wickham T J, DeGregori J, Bergelson J M, Currier M A
Abstract excerpt
Exploiting the lytic life cycle of viruses has gained recent attention as an anticancer strategy (oncolysis). To explore the utility of adenovirus (Ad)-mediated oncolysis for rhabdomyosarcoma (RMS), we tested RMS cell lines for Ad gene transduction and infection. RMS cells were variably transduced by Ad. Compared with control cells, RMS cells were less sensitive or even resistant to oncolysis by wild-type virus....
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