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Effective High-Capacity Gutless Adenoviral Vectors Mediate Transgene Expression in Human Glioma Cells

24 Jun 2006

Abstract excerpt

Glioblastoma multiforme (GBM) is the most common subtype of primary malignant brain tumor. Although serotype 5 adenoviral vectors (Ads) have been used successfully in clinical trials for GBM, the capacity of Ads to infect human glioma cells and the expression of adenoviral receptors in GBM cells have been challenged. In this report, we studied the expression of three molecules that have been shown to mediate...

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PMID: 16798098
DOI: 10.1016/j.ymthe.2006.05.006

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