Article
High-efficiency transduction of fibroblasts and mesenchymal stem cells by tyrosine-mutant AAV2 vectors for their potential use in cellular therapy.
Human gene therapy - 1 Nov 2010
Li Mengxin, Jayandharan Giridhara R, Li Baozheng, Ling Chen, Ma Wenqin, Srivastava Arun, Zhong Li
Abstract excerpt
Adeno-associated virus 2 (AAV2) vectors transduce fibroblasts and mesenchymal stem cells (MSCs) inefficiently, which limits their potential widespread applicability in combinatorial gene and cell therapy. We have reported that AAV2 vectors fail to traffic efficiently to the nucleus in murine fibroblasts. We have also reported that site-directed mutagenesis of surface-exposed tyrosine residues on viral capsids...
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