Altered seizure susceptibility in mice lacking the Ca(v)2.3 E-type Ca2+ channel.

doi:10.1111/j.1528-1167.2006.00541.x

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Article

Altered seizure susceptibility in mice lacking the Ca(v)2.3 E-type Ca2+ channel.

Epilepsia - 1 May 2006

Weiergräber Marco, Henry Margit, Krieger Andreas, Kamp Marcel, Radhakrishnan Kayalvizhi, Hescheler Jürgen, Schneider Toni

Abstract excerpt

PURPOSE: Recently the Ca(v)2.3 (E/R-type) voltage-gated calcium channel (VGCC) has turned out to be not only a potential target for different antiepileptic drugs (e.g., lamotrigine, topiramate) but also a crucial component in the pathogenesis of absence epilepsy, human juvenile myoclonic epilepsy (JME), and epileptiform activity in CA1 neurons. The aim of our study was to perform an electroencephalographic...

Topics

4-Aminopyridine
Animals
Blotting, Western
Calcium Channels
Calcium Channels, T-Type
Disease Models, Animal
Electrodes, Implanted
Electroencephalography
Electromyography
Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Hippocampus

Ion Channel Gating

Mice

Mice, Knockout

Pentylenetetrazole

Reverse Transcriptase Polymerase Chain Reaction

Seizures

Source

Open in PubMed

Identifiers

PMID: 16686648
DOI: 10.1111/j.1528-1167.2006.00541.x

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