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Article

Meningitis caused by a lipopolysaccharide deficient Neisseria meningitidis.

The Journal of infection - 1 Oct 2014

Piet Jurgen R, Zariri Afshin, Fransen Floris, Schipper Kim, van der Ley Peter, van de Beek Diederik, van der Ende Arie

Abstract excerpt

OBJECTIVE: Lipopolysaccharide (LPS) is a major component of the Neisseria meningitidis outer membrane. Here we report a patient with meningococcal meningitis of which the causative isolate lacked LPS. Thus far, no naturally occurring LPS-deficient meningococcal isolate has been known to cause clinical disease. METHODS: We used SDS-PAGE, silver staining and LPS-specific antibodies in whole cell ELISA to determine...

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PMID: 24932738
DOI: 10.1016/j.jinf.2014.06.005

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