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Article

A novel melanocortin 3 receptor gene (MC3R) mutation associated with severe obesity.

The Journal of clinical endocrinology and metabolism - 1 Mar 2002

Lee Yung-Seng, Poh Larry Kok-Seng, Loke Kah-Yin

Abstract excerpt

UNLABELLED: The melanocortin 3 receptor (MC3R) plays a critical role in weight regulation as demonstrated in mouse models. We describe a novel mutation Ile183Asn (T548A) found in heterozygosity in a 13-year-old obese girl and her father. METHODS: The MC3R gene was sequenced in 41 unrelated obese children, and 121 DNA samples from non-obese individuals were analysed for this novel sequence variant by...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 11889220
DOI: 10.1210/jcem.87.3.8461

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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