Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Modeling tissue- and mutation- specific electrophysiological effects in the long QT syndrome: role of the Purkinje fiber.

PloS one - 1 Jan 2014

Iyer Vivek, Sampson Kevin J, Kass Robert S

Abstract excerpt

Congenital long QT syndrome is a heritable family of arrhythmias caused by mutations in 13 genes encoding ion channel complex proteins. Mounting evidence has implicated the Purkinje fiber network in the genesis of ventricular arrhythmias. In this study, we explore the hypothesis that long QT mutations can demonstrate different phenotypes depending on the tissue type of expression. Using computational models of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Action Potentials
Share to Arrhythmias, Cardiac
Share to Electrophysiological Phenomena

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Heart Ventricles

Share to Ion Channel Gating

Share to Long QT Syndrome

Share to Models, Cardiovascular

Share to NAV1.5 Voltage-Gated Sodium Channel

Source

Open in PubMed Open full text

Identifiers

PMID: 24892747
DOI: 10.1371/journal.pone.0097720
PMCID: PMC4043730

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Modeling tissue- and mutation- specific electrophysiological effects in the long QT syndrome: role of the Purkinje fiber.PMID 24892747Read ↗

Proarrhythmia in KCNJ2-linked short QT syndrome: insights from modelling.Semantic proximity Read ↗

Human atrial fibrillation and genetic defects in transient outward currents: mechanistic insights from multi-scale computational models.Semantic proximity Read ↗

Atrial arrhythmogenicity of KCNJ2 mutations in short QT syndrome: Insights from virtual human atria.Semantic proximity Read ↗

Modeling of IK1 mutations in human left ventricular myocytes and tissue.Semantic proximity Read ↗

Modeling incomplete penetrance in long QT syndrome type 3 through ion channel heterogeneity: an in silico population study.Semantic proximity Read ↗

Modeling genetic cardiac channelopathies using induced pluripotent stem cells - Status quo from an electrophysiological perspective.Semantic proximity Read ↗

Purkinje Cells as Sources of Arrhythmias in Long QT Syndrome Type 3.Semantic proximity Read ↗

Computational analysis of arrhythmogenesis in KCNH2 T618I mutation-associated short QT syndrome and the pharmacological effects of quinidine and sotalol.Semantic proximity Read ↗

Na(+) channel mutation that causes both Brugada and long-QT syndrome phenotypes: a simulation study of mechanism.Semantic proximity Read ↗

Role of natural inter-individual variability in the different penetrance of congenital long QT syndromes (LQTS) types 1 and 2: an in silico approach.Semantic proximity Read ↗

Quantitative prediction of the arrhythmogenic effects of de novo hERG mutations in computational models of human ventricular tissues.Semantic proximity Read ↗

Long QT syndrome: biophysical and pharmacologic mechanisms in LQT3.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.