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Article

Novel mechanism of regulation of Rac activity and lamellipodia formation by RET tyrosine kinase.

The Journal of biological chemistry - 24 May 2002

Fukuda Toshifumi, Kiuchi Kazutoshi, Takahashi Masahide

Abstract excerpt

Rac activation in neuronal cells plays an important role in lamellipodia formation that is a critical event for neuritogenesis. It is well known that the Rac activity is regulated via activation of phosphatidylinositol 3-kinase (PI3K) by a variety of receptor tyrosine kinases. Here we show that increased serine phosphorylation on RET receptor tyrosine kinase following cAMP elevation promotes lamellipodia...

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Source

Identifiers

PMID: 11886862
DOI: 10.1074/jbc.M200643200

Genes

RET
GDNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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