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Article

Activation of BMK1 via tyrosine 1062 in RET by GDNF and MEN2A mutation.

Biochemical and biophysical research communications - 2 Mar 2001

Hayashi Y, Iwashita T, Murakamai H, Kato Y, Kawai K, Kurokawa K, Tohnai I, Ueda M, Takahashi M

Abstract excerpt

Big mitogen-activated protein kinase 1 (BMK1) is a new member of mitogen-activated protein kinase (MAPK) family. In the present study, we investigated whether glial cell line-derived neurotrophic factor (GDNF) can induce activation of BMK1 through RET tyrosine kinase. Its activation reached a maximal level at 30 min and continued at least for 120 min after GDNF stimulation. In addition, we detected BMK1...

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Share to Glial Cell Line-Derived Neurotrophic Factor
Share to Glial Cell Line-Derived Neurotrophic Factor Receptors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mitogen-Activated Protein Kinases

Share to Multiple Endocrine Neoplasia Type 2a

Share to Nerve Growth Factors

Share to Phosphoinositide-3 Kinase Inhibitors

Share to Proto-Oncogene Proteins c-ret

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Source

Identifiers

PMID: 11237712
DOI: 10.1006/bbrc.2001.4338

Genes

GDNF
RET

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Activation of BMK1 via tyrosine 1062 in RET by GDNF and MEN2A mutation.PMID 11237712Read ↗

Intracellular RET signaling pathways activated by GDNFSemantic proximity Read ↗

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Mixed-lineage kinase 3 regulates B-Raf through maintenance of the B-Raf/Raf-1 complex and inhibition by the NF2 tumor suppressor protein.Semantic proximity Read ↗

Biochemical and biological responses induced by coupling of Gab1 to phosphatidylinositol 3-kinase in RET-expressing cells.Semantic proximity Read ↗

Analysis of Ret knockin mice reveals a critical role for IKKs, but not PI 3-K, in neurotrophic factor-induced survival of sympathetic neurons.Semantic proximity Read ↗

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RET signaling-induced SPHK1 gene expression plays a role in both GDNF-induced differentiation and MEN2-type oncogenesis.Semantic proximity Read ↗

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