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Article

Dnmt1 overexpression causes genomic hypermethylation, loss of imprinting, and embryonic lethality.

Molecular and cellular biology - 1 Apr 2002

Biniszkiewicz Detlev, Gribnau Joost, Ramsahoye Bernard, Gaudet François, Eggan Kevin, Humpherys David, Mastrangelo Mary-Ann, Jun Zhan, Walter Jörn, Jaenisch Rudolf

Abstract excerpt

Biallelic expression of Igf2 is frequently seen in cancers because Igf2 functions as a survival factor. In many tumors the activation of Igf2 expression has been correlated with de novo methylation of the imprinted region. We have compared the intrinsic susceptibilities of the imprinted region of Igf2 and H19, other imprinted genes, bulk genomic DNA, and repetitive retroviral sequences to Dnmt1 overexpression. At...

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Identifiers

PMID: 11884600
DOI: 10.1128/MCB.22.7.2124-2135.2002
PMCID: PMC133685

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Dnmt1 overexpression causes genomic hypermethylation, loss of imprinting, and embryonic lethality.PMID 11884600Read ↗

Igf2-H19, an imprinted tandem gene, is an important regulator of embryonic development, a guardian of proliferation of adult pluripotent stem cells, a regulator of longevity, and a ‘passkey’ to cancerogenesisSemantic proximity Read ↗

A complex duplication created by gene targeting at the imprinted H19 locus results in two classes of methylation and correlated Igf2 expression phenotypes.Semantic proximity Read ↗

The human and mouse H19 imprinting control regions harbor an evolutionarily conserved silencer element that functions on transgenes in Drosophila.Semantic proximity Read ↗

Genomic Deletion of an Imprint Maintenance Element Abolishes Imprinting of Both Insulin-like Growth Factor II andH19Semantic proximity Read ↗

Deletion of a silencer element in Igf2 results in loss of imprinting independent of H19Semantic proximity Read ↗

Symmetric and asymmetric DNA methylation in the human IGF2-H19 imprinted region.Semantic proximity Read ↗

Tissue-specific insulator function at H19/Igf2 revealed by deletions at the imprinting control region.Semantic proximity Read ↗

Multiple imprinted sense and antisense transcripts, differential methylation and tandem repeats in a putative imprinting control region upstream of mouse Igf2.Semantic proximity Read ↗

Regulatory mechanisms at the mouse Igf2/H19 locus.Semantic proximity Read ↗

Hypermethylation of the IGF2 differentially methylated region 2 is a specific event in insulinomas leading to loss-of-imprinting and overexpressionSemantic proximity Read ↗

Role for DNA methylation in genomic imprinting.Semantic proximity Read ↗

Loss of the maternal H19 gene induces changes in Igf2 methylation in both cis and trans.Semantic proximity Read ↗

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