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Article

Birth of parthenogenetic mice that can develop to adulthood.

Nature - 22 Apr 2004

Kono Tomohiro, Obata Yayoi, Wu Quiong, Niwa Katsutoshi, Ono Yukiko, Yamamoto Yuji, Park Eun Sung, Seo Jeong-Sun, Ogawa Hidehiko

Abstract excerpt

Only mammals have relinquished parthenogenesis, a means of producing descendants solely from maternal germ cells. Mouse parthenogenetic embryos die by day 10 of gestation. Bi-parental reproduction is necessary because of parent-specific epigenetic modification of the genome during gametogenesis. This leads to unequal expression of imprinted genes from the maternal and paternal alleles. However, there is no direct...

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Identifiers

PMID: 15103378
DOI: 10.1038/nature02402

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Birth of parthenogenetic mice that can develop to adulthood.PMID 15103378Read ↗

Genomic imprinting is a barrier to parthenogenesis in mammalsSemantic proximity Read ↗

Mouse parthenogenetic embryos with monoallelic H19 expression can develop to day 17.5 of gestation.Semantic proximity Read ↗

Regulated expression of two sets of paternally imprinted genes is necessary for mouse parthenogenetic development to termSemantic proximity Read ↗

Appropriate expression of imprinted genes on mouse chromosome 12 extends development of bi-maternal embryos to term.Semantic proximity Read ↗

Disruption of primary imprinting during oocyte growth leads to the modified expression of imprinted genes during embryogenesis.Semantic proximity Read ↗

Adult bi-paternal offspring generated through direct modification of imprinted genes in mammalsSemantic proximity Read ↗

The non-viability of uniparental mouse conceptuses correlates with the loss of the products of imprinted genes.Semantic proximity Read ↗

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Biallelic expression of imprinted genes in the mouse germ line: implications for erasure, establishment, and mechanisms of genomic imprinting.Semantic proximity Read ↗

Epigenetic modifications during oocyte growth correlates with extended parthenogenetic development in the mouse.Semantic proximity Read ↗

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