Article
The non-viability of uniparental mouse conceptuses correlates with the loss of the products of imprinted genes.
Mechanisms of development - 1 Apr 1994
Walsh C, Glaser A, Fundele R, Ferguson-Smith A, Barton S, Surani M A, Ohlsson R
Abstract excerpt
Diploid parthenogenetic or androgenetic mouse conceptuses produce characteristic and opposite mutant phenotypes and are non-viable, presumably due to different contributions from the maternal and paternal genomes. This is likely to be the result of the preferential expression of only one parent's copy of certain genes in the offspring. So far, four such endogenous imprinted genes are known: the paternal alleles...
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