Article
Appropriate expression of imprinted genes on mouse chromosome 12 extends development of bi-maternal embryos to term.
FEBS letters - 13 Nov 2007
Kawahara Manabu, Wu Qiong, Ferguson-Smith Anne C, Kono Tomohiro
Abstract excerpt
Recently, we reported that the restored regulation of imprinted gene expression from two regions -H19 differentially methylated region (H19-DMR) and intergenic germline-derived DMR (IG-DMR) - is sufficient for accomplishing full-term development in mice. In the present study, we determined the developmental ability of the bi-maternal embryos (BMEs) containing the non-growing oocyte genome with the IG-DMR deletion...
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