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Article

The positive activator of cephamycin C and clavulanic acid production in Streptomyces clavuligerus is mistranslated in a bldA mutant.

Microbiology (Reading, England) - 1 Mar 2002

Trepanier Nicole K, Jensen Susan E, Alexander Dylan C, Leskiw Brenda K

Abstract excerpt

In Streptomyces coelicolor bldA encodes the principal leucyl tRNA for translation of UUA codons and controls pigmented antibiotic production by the presence of TTA codons in the genes encoding the pathway-specific activators of actinorhodin and undecylprodigiosin biosynthesis. In Streptomyces clavuligerus the gene encoding the pathway-specific activator of both cephamycin C and clavulanic acid production, ccaR,...

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Source

Identifiers

PMID: 11882698
DOI: 10.1099/00221287-148-3-643

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Research trail→

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The positive activator of cephamycin C and clavulanic acid production in Streptomyces clavuligerus is mistranslated in a bldA mutant.PMID 11882698Read ↗

The Gene bldA, a regulator of morphological differentiation and antibiotic production in streptomyces.Semantic proximity Read ↗

The level of a transcript required for production of a Streptomyces coelicolor antibiotic is conditionally dependent on a tRNA gene.Semantic proximity Read ↗

A rare leucine codon in adpA is implicated in the morphological defect of bldA mutants of Streptomyces coelicolor.Semantic proximity Read ↗

tRNA accumulation and suppression of the bldA phenotype during development in Streptomyces coelicolor.Semantic proximity Read ↗

The bldA-encoded tRNA is poorly expressed in the bldI mutant of Streptomyces coelicolor A3(2).Semantic proximity Read ↗

Construction and analysis of ss-lactamase-inhibitory protein (BLIP) non-producer mutants of Streptomyces clavuligerus.Semantic proximity Read ↗

Colonial differentiation in Streptomyces coelicolor depends on translation of a specific codon within the adpA gene.Semantic proximity Read ↗

Expression of the Streptomyces alboniger pur cluster in Streptomyces lividans is dependent on the bldA-encoded tRNALeu.Semantic proximity Read ↗

Interdependence of gene expression for early steps of cephalosporin synthesis in Streptomyces clavuligerus.Semantic proximity Read ↗

A pathway-specific transcriptional activator regulates late steps of clavulanic acid biosynthesis in Streptomyces clavuligerus.Semantic proximity Read ↗

The claR gene of Streptomyces clavuligerus, encoding a LysR-type regulatory protein controlling clavulanic acid biosynthesis, is linked to the clavulanate-9-aldehyde reductase (car) gene.Semantic proximity Read ↗

The Streptomyces coelicolor A3(2) bldB region contains at least two genes involved in morphological development.Semantic proximity Read ↗

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