Article
The claR gene of Streptomyces clavuligerus, encoding a LysR-type regulatory protein controlling clavulanic acid biosynthesis, is linked to the clavulanate-9-aldehyde reductase (car) gene.
Gene - 12 May 1998
Pérez-Redondo R, Rodríguez-García A, Martín J F, Liras P
Abstract excerpt
Two genes, claR and car, encoding proteins involved in clavulanic acid biosynthesis, have been found in a 2.8-kb BglII-EcoRI DNA fragment of Streptomyces clavuligerus adjacent to the region containing the cephamycin and clavulanic acid biosynthesis gene cluster. claR encoded a protein of 431 amin...
Topics
- Alcohol Oxidoreductases
- Aldehyde Reductase
- Amino Acid Sequence
- Bacterial Proteins
- Base Sequence
- Clavulanic Acid
- Cloning, Molecular
- Codon, Initiator
- Gene Amplification
- Gene Dosage
- Gene Expression Regulation, Bacterial
- Gene Expression Regulation, Enzymologic
- Genes, Bacterial
- Genetic Linkage