Article
A pathway-specific transcriptional activator regulates late steps of clavulanic acid biosynthesis in Streptomyces clavuligerus.
Molecular microbiology - 1 Feb 1998
Paradkar A S, Aidoo K A, Jensen S E
Abstract excerpt
A Streptomyces clavuligerus gene (designated claR) located downstream from the gene encoding clavaminate synthase in the clavulanic acid biosynthetic gene cluster is involved in regulation of the late steps in clavulanic acid biosynthesis. Nucleotide sequence analysis and database searching of Cl...
Topics
- Amino Acid Sequence
- Clavulanic Acid
- Mixed Function Oxygenases
- Molecular Sequence Data
- Multigene Family
- Mutation
- Open Reading Frames
- Sequence Analysis, DNA
- Sequence Homology, Amino Acid
- Streptomyces
- Trans-Activators
- Transcription, Genetic
- Transcriptional Activation