Article
Interdependence of gene expression for early steps of cephalosporin synthesis in Streptomyces clavuligerus.
Annals of the New York Academy of Sciences - 2 May 1994
Demain A L, Piret J M, Yu H, Coque J J, Liras P, Martin J F
Abstract excerpt
The early steps of cephamycin synthesis by S. clavuligerus are catalyzed sequentially by lysine epsilon-aminotransferase (LAT), delta-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine synthetase (ACVS) and isopenicillin N synthase (cyclase, IPNS). The genes (lat, pcbAB, and pcbC, respectively) are close...
Topics
- Cephalosporins
- Cloning, Molecular
- Gene Expression
- Genes, Bacterial
- Genetic Engineering
- L-Lysine 6-Transaminase
- Mutation
- Oxidoreductases
- Peptide Synthases
- Promoter Regions, Genetic
- Streptomyces
- Transaminases