The level of a transcript required for production of a Streptomyces coelicolor antibiotic is conditionally dependent on a tRNA gene.

doi:10.1128/jb.172.11.6189-6193.1990

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Article

The level of a transcript required for production of a Streptomyces coelicolor antibiotic is conditionally dependent on a tRNA gene.

Journal of bacteriology - 1 Nov 1990

Guthrie E P, Chater K F

Abstract excerpt

In Streptomyces coelicolor A3(2), bldA mutants are conditionally defective in aerial mycelium formation and fail to synthesize all four antibiotics produced by bldA+ strains. Previous studies showed that bldA specifies the tRNA for the rarely used leucine codon UUA. Here we describe experiments e...

Topics

Anti-Bacterial Agents
Catechol 2,3-Dioxygenase
Cloning, Molecular
DNA, Bacterial
Dioxygenases
Genes, Bacterial
Genes, Regulator
Genotype
Oxygenases
Plasmids
RNA, Transfer
Streptomyces
Transcription, Genetic

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