Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The level of a transcript required for production of a Streptomyces coelicolor antibiotic is conditionally dependent on a tRNA gene.

Journal of bacteriology - 1 Nov 1990

Guthrie E P, Chater K F

Abstract excerpt

In Streptomyces coelicolor A3(2), bldA mutants are conditionally defective in aerial mycelium formation and fail to synthesize all four antibiotics produced by bldA+ strains. Previous studies showed that bldA specifies the tRNA for the rarely used leucine codon UUA. Here we describe experiments examining the abundance in a bldA mutant of a transcript involved in antibiotic production. With use of a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anti-Bacterial Agents
Share to Cloning, Molecular
Share to DNA, Bacterial

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genes, Bacterial

Share to Genes, Regulator

Share to Genotype

Share to Plasmids

Share to Transcription, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 2228956
DOI: 10.1128/jb.172.11.6189-6193.1990
PMCID: PMC526799

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The level of a transcript required for production of a Streptomyces coelicolor antibiotic is conditionally dependent on a tRNA gene.PMID 2228956Read ↗

tRNA accumulation and suppression of the bldA phenotype during development in Streptomyces coelicolor.Semantic proximity Read ↗

The bldA-encoded tRNA is poorly expressed in the bldI mutant of Streptomyces coelicolor A3(2).Semantic proximity Read ↗

The Gene bldA, a regulator of morphological differentiation and antibiotic production in streptomyces.Semantic proximity Read ↗

The positive activator of cephamycin C and clavulanic acid production in Streptomyces clavuligerus is mistranslated in a bldA mutant.Semantic proximity Read ↗

Pleiotropic regulatory genes bldA, adpA and absB are implicated in production of phosphoglycolipid antibiotic moenomycin.Semantic proximity Read ↗

A new TetR family transcriptional regulator required for morphogenesis in Streptomyces coelicolor.Semantic proximity Read ↗

Developmentally regulated cleavage of tRNAs in the bacterium Streptomyces coelicolor.Semantic proximity Read ↗

Expression of the regulatory protein LndI for landomycin E production in Streptomyces globisporus 1912 is controlled by the availability of tRNA for the rare UUA codon.Semantic proximity Read ↗

A rare leucine codon in adpA is implicated in the morphological defect of bldA mutants of Streptomyces coelicolor.Semantic proximity Read ↗

Expression of the Streptomyces alboniger pur cluster in Streptomyces lividans is dependent on the bldA-encoded tRNALeu.Semantic proximity Read ↗

sigma(BldN), an extracytoplasmic function RNA polymerase sigma factor required for aerial mycelium formation in Streptomyces coelicolor A3(2).Semantic proximity Read ↗

The bkdR gene of Streptomyces coelicolor is required for morphogenesis and antibiotic production and encodes a transcriptional regulator of a branched-chain amino acid dehydrogenase complex.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.