Article
Interaction of alpha(1)-Na,K-ATPase and Na,K,2Cl-cotransporter genes in human essential hypertension.
Hypertension (Dallas, Tex. : 1979) - 1 Aug 2001
Glorioso N, Filigheddu F, Troffa C, Soro A, Parpaglia P P, Tsikoudakis A, Myers R H, Herrera V L, Ruiz-Opazo N
Abstract excerpt
Essential hypertension is a common disease the genetic determinants of which have been difficult to unravel because of its clinical heterogeneity and complex, multifactorial, polygenic etiology. Based on our observations that alpha(1)-Na,K-ATPase (ATP1A1) and renal-specific, bumetanide-sensitive Na,K,2Cl-cotransporter (NKCC2) genes interactively increase susceptibility to hypertension in the Dahl salt-sensitive...
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